Genomics Books
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Gulp! I actually UNDERSTOOD heavy science!Review Date: 2008-09-21
TRACE YOUR ROOTS WITH DNAReview Date: 2008-08-23
Megan Smolenyak "Trace Your Roots with DNA" - reviewedReview Date: 2008-02-05
Anyone starting their "Roots" research effort is advised to buy this book. It will help you save money by allowing DNA to focus on your line and not someone elses. Read the book for more details!
Useful, but could be betterReview Date: 2008-10-24
This is a "Must Have" addition to your DNA library...Review Date: 2007-09-03
Of the 12-15 books I have purchased so far, Megan Smolenyak's touchstone reference work continues to be the one I reach for when I have a question myself.
Easily read and understood, this book makes complex concepts readily accessible with clear illustrations, definitions, real-world examples, and authoritative references when needed. I am not naturally science-minded, but as a good researcher, I want to be able to use every tool in the box. This is my go-to book for that purpose.
Buy as many DNA books and tapes as you want, but your DNA library will not be complete without this classic introduction to the concepts involved in genetic genealogy.
I highly recommend it!
CHT in Virginia


Amazing bookReview Date: 2008-03-26
Taking back the factsReview Date: 2007-03-05
Sex, Drugs & DNAReview Date: 2006-09-30
A must read for anyone who votes!!Review Date: 2006-11-19
A Must Read for Young and Developing ScientistsReview Date: 2006-09-26
I was personally very impressed with his first chapter. It is something that I would highly recommend to most young and developing scientists. I feel it gives an honest and needed look at what they will be dealing with in the near future.
Michael Stebbins makes this foray into the world of a science an entertaining and informative journey. I highly recommend it.

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ExcellentReview Date: 2007-05-06
Useful TextReview Date: 2003-10-17
User FriendlyReview Date: 2002-12-11
MasterpieceReview Date: 2002-11-19
Marvelous TextReview Date: 2003-01-23

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A Book That MattersReview Date: 2007-11-01
An Eye Opener on Risk in Our Brave New WorldReview Date: 2008-05-06
Intervention is fantasticReview Date: 2007-10-29
We need more books like thisReview Date: 2007-11-28
I would feel more confident if more scientists understood the problems it raises.
Caruso develops an aproach that, I am convinced, we should encourage. An atitude of openness and cautiousness in front of what's changing and that we don't know. Be there, participate with a critical mind might be the smartest way of entering the future as we make it happen. Be open to all stakeholders knowledge and understanding might be the safest way to move forward.
This is one of the most difficult thing I can think of. But Caruso is of considerable help with the processes she suggests we should adopt.
Asilomar was in 1975. Now what?Review Date: 2007-10-30
Intervention is mainly about transgenic organisms. One of the numerous unsolved problems people need to tackle this century is devising a workable regulatory framework for transgenic plants and animals, aka genetically modified organisms, aka organisms into which engineers have dropped pieces of DNA. In the US, the existing regulatory regime is a patchwork. The biggest part of the patchwork comes from at the dawn of recombinant DNA work at the Asilomar conference in 1975. Asilomar led directly to the "NIH guidelines". These guesstimated different levels of potential risk for different kinds of recombinant DNA experiments, mandated lab practices and levels of containment to conduct research at each level, and set up bodies for review and approval of experiments local to each university. Asilomar also brought about the establishment of an overarching national body, the Recombinant Advisory Committee (aka RAC) to rule on the appropriate level of containment for contested experiments, and established mechanisms by which levels of containment could be ratcheted up or down in response to information coming from new experiments, which in practice has led to sunset of most of the most burdensome regulations as the feared risks did not materialize. The regulatory framework affected experiments in universities funded by the US government, but was extended to commercial work via local communities. Individual cities caused, via their control of zoning, biotech firms to follow the NIH rules. Most of this "Asilomar framework" governs recombinant DNA research in lab organisms such as E. coli, yeast, and mice. In the US, use of recombinant DNA in people, for example in gene therapy, is regulated by the FDA, and release of an organism into the environment, for example a herbicide-resistant potato or an oil-eating bacterium, is regulated by the EPA.
Recombinant work is also regulated in other advanced countries, but in no country is there a system of local and national oversight as strong as that in the US. And the US framework, 32 years old, is fraying at the seams. It is showing its age by showing gaps. Many of the issues are due to the Moore's-law-like growth in the scope and power of the technologies, the democratization of the technical ability to hack DNA, the adoption of recombinant DNA methods by new classes of hackers , and the use of recombinant DNA to engineer different classes of organisms.
The Asilomar framework was designed to regulate research in universities and, extended by zoning regulations, in companies. The Asilomar framework was not designed for a world in which the number of people with basic training in recombinant DNA methods has increased from hundreds to tens or hundreds of thousands worldwide. For example, in most US localities, the only framework that governs recombinant DNA work by private citizens is that sometimes provided by local zoning regulations; and this at a time when affluent parents can and do outfit labs for their high school aged children.
But perhaps the most public change since Asilomar is the increase in the number of different engineered organisms intended to be used outside of the lab. Here, agriculture has emerged as a flashpoint. Last year most of the dollar value of the US corn, soybean, and cotton crops came from transgenic plants. Although introduction of recombinant crops in Europe is stalled, due in part to old fashioned trade protectionism, worldwide, farmers are planting them everywhere they can, from Brasil, where the Lula regime retroactively legalized herbicide resistant soybean seed in the face of the fact that farmers were enthusiastically smuggling in metric tons of the stuff from Argentina and Paraguay, to China and India, where genetically modified insect-resistant rice seed, probably made by multiple independent firms, has been sold since at least 2005. In agriculture, without outright prohibition, the spread of genetically engineered plants and animals is likely to continue until most species of economic importance have been engineered. But even though farmers may love the stuff, it turns out that people tend to view technologies such the recombinant DNA that enables transgenic plants as affecting their lives. Moreover, many may feel that the changes the technologies are bringing are occurring without their understanding or consent.
In Intervention, Caruso uses this steady increase in the contribution of genetic engineering to the economy as a test case, an example to consider how new technologies might be regulated. The book requires the reader to face the question of what an international regulatory framework for recombinant DNA work and genetic engineering of organisms should look like.
Caruso does not lay out solutions, but she does describes processes for involving larger numbers of stakeholders in decisionmaking, promising tactics to provide additional ways for societies to get a handle on the pace of technical change.
Intervention is not horatory, it is not prescriptive. Caruso raises issues and suggests mechanisms that might help address them, but does not provide a ten point set of solutions. I find this aspect of the book to be a strength, although as a consequence the book leaves the reader with many more questions than answers. Here, I will mention two.
First, at the moment, in the US, a new technology is typically regulated only after has been shown to cause harm, and, by law, the degree of regulation is based on assessed risk, and the assessment of risk is supposed to be based on the best science available. Overall, at least for recombinant DNA, I believe that this conceptual framework for regulation has worked pretty well (To my knowledge there has only been one death directly attributable by recombinant DNA (the child Jesse Gelsinger, who died during an experimental gene therapy trial in the 1990s from a dose of a gene therapy vector that should never have been allowed by the local review committee)). But there are other ideas on which regulation can be based. Should the US exchange this basis for regulation for that used in the EU, grounded in "precautionary principle", derived from German Social Democratic legal theory in the 1930s, even if to do so were to carry a cost of delaying the benefits new technologies might bring?
Second, in part because of the science-based risk assessment mandated in the US, people who feel uneasy about a new technology or who simply dislike it are almost always required to assert that their opposition or unease is due to the fact that the technology presents a risk. Why always talk piously about risk if the real issue that one finds some work of engineering distasteful (Caruso even has a term for this, the "ugh factor")? In a democracy, should widespread dislike, by itself, ever constitute grounds for regulating or even prohibiting a technology? If not, why not?
I hope that the publication Denise Caruso's Intervention marks the start of a broader discussion, one that might help societies gain better control of technical change and its consequences.

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Scientific journalism at it's bestReview Date: 2007-07-24
Hard to put down!Review Date: 2005-10-14
This is not a dry chronicle of the scientific methods, technological and computational breakthroughs that made this great accomplishment possible. Rather, Shreeve manages to guide the layman through the intricacies of all of the above, while never loosing site of the more interesting story of the personalities and interactions among the key players in this story. There are lessons here for anyone - integrity, vision, politics, business, perception and the law of unintended consequences.
The best book I've read this year.
Unveiling the meaning of lifeReview Date: 2005-07-02
A fascinating and exciting journey!Review Date: 2005-09-08
The distinguished feature of this book is its style of writing. It is incredibly simple and straight forward, without any unncessary twist of language or logic. Although this is a depiction of the whole story behind the Human Genome Project, it reads like an epic tale of a breathtaking journey.
James Shreeve gives a close account of all the events that led up to sequencing of human genome, including politics, science, business, legal matters and personal relations. What's more, is that a lay reader who understands nothing about gene or molecular biology can learn a whole lot of things he didn't know before. While the book is not technical in biological and other scientific explanations, it is sufficient to explain to the lay reader about genes, their importance as well as their pharamaceutical value.
This book, like other reviewers have mentioned, is truly hard to put down. Highly recommended to everyone!!
Stunning! Superlative! Exciting!Review Date: 2005-07-17
Exciting. At times depressing. Full of real people at war with real problems and real results.


An Excellent and Interesting BookReview Date: 2008-10-17
A real thriller!Review Date: 2008-07-26
Fascinating BookReview Date: 2008-07-22
A great read - you will not be able to put it downReview Date: 2008-07-01
Great ReadReview Date: 2008-01-29

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Fantastic book!Review Date: 2007-09-08
useful bookReview Date: 2007-08-09
Save on TextbookReview Date: 2006-08-15
Best Basic Book on Tisssue CultureReview Date: 2006-07-07
The best book on cell cultureReview Date: 2005-01-08

userReview Date: 2007-09-04
Start from very basic phenomena and go further to the molecular level. Easy to read for anyone who is interested in this field.
DNA to Diversity Review Date: 2008-06-15
Evo-Devo For The Graduate StudentReview Date: 2006-09-06
We have about 25,000 genes. Some of these are "tool kit" genes that we share with all other animals. They evolved well before the Cambrian explosion over 540 million years ago from a bilaterally symmetrical common ancestor. Almost exact counterparts are found in apes and mice, and close counterparts in arthropods and worms. Next to most genes is a stretch of so-called "junk DNA" that does not code for genes. These DNA segments contain from three to twenty (or more) switches that collectively turn that gene on or off. The switches are activated or repressed by the differing concentration gradients of the protein products of other genes produced by neighboring cells. By virtue of the servo-feedback loops creating unique combinations of the protein products of tool kit genes, cells of the early embryo create a geographical map of their future body.
An escalating orchestra of domino effects builds complexity, each new development affecting the others. The tool kit genes and the other core genes that control biochemical function from bacteria to man are resistant to mutation. Novelty and speciation comes from the infinite variety of changes that come from the readily mutable genetic switches - allowing for changes in a segment without mortally wounding the rest of the animal. Not a single biologist 40 years ago would have predicted these discoveries.
The exciting developments of evo-devo have sent jolts of electricity through the evolutionary community. Nothing basic has been overturned; much has been enhanced. For example: It used to be thought that eyes had evolved independently many, many times - after all, the lumps of light sensitivity in primitive wormlike creatures, the compound eyes of insects, and the eyes of mammals have more differences than commonalities. As it turns out, the making of each eye-like organ is directed by a PAX6 tool kit gene. Not only that, if the PAX6 gene from the mouse is artificially introduced into the genetic material destined for the leg of the fly, an eye will form on the fly leg...and it's not a mouse eye - it's a fly eye. The mouse PAX6 gene switches - influenced by chemical gradients from adjacent tissue in the fly embryo - cause the gene to produce a fly eye! Astounding!
Tool kit genes (and other genes) are frequently named after the anomaly that doesn't develop when that gene is absent. The TINMAN gene controls development of the heart and circulatory system from butterflies to badgers - named after the Wizard of Oz character who had no heart. The wealth of information presented in this book will surprise, educate, and entertain the reader - and evo-devo researchers have just scratched the surface. New graduates in biology are surging into this explosive and previously neglected science.
There are three other books that I know of that cover these captivating discoveries of the last 30 years:
"Coming to Life," by Christiane Nusslein-Volhard. This fine book, written by a Nobel Prize winner for her meticulous ground-breaking work on fruit flies emphasizes the concentration gradients, which are indeed central to the story.
"The Plausibility of Life," by Kirschner and Gerhart. These authors are so excited about the new findings, they think it deserves a name - facilitated variation - and of course, they thought of the name. It is an excellent book with more basic sciences than the book under review, emphasizing how evo-devo facilitates novelty through an enhanced Baldwin Effect.
"Endless Forms Most Beautiful," also by Sean B. Carroll, written more for the college graduate who has taken a little biology.
I have studied them all. For the general public, "Endless Forms Most Beautiful" is the best. For those more familiar with molecular biochemistry and genetics, "DNA to Diversity" contains much more specific information - although anyone who would like one book would like the other.
"From DNA to Diversity" is a superbly written book -essential reading for the advanced reader who wishes to keep up with the stunning advances that have occurred in evolutionary knowledge during the past thirty years.
Which Evo-Devo Book for You?Review Date: 2005-11-15
My own background is this: My formal education in biology consisted of an introductory course in college 40-odd years ago. Since then I've read a lot and in the last two years I've had a very strong interest in molecular and evolutionary biology. (For more info, click on my name, above. My Profile also has a link to my Listmania list of evolution books. Note that you don't have to be a grad student to read this book.)
I read From DNA to Diversity first and it was too much for me. I then read Endless Forms. That was pretty understandable, so I went back to Diversity and found it reasonable clear. I have since read it a third time and I am very fond of it.
Of the thousands of genes involved in the early development of animals, this book concentrates on a few, along with the proteins with which they interact and the various body parts they affect. Special attention is paid to the Hox genes and their insect homologues. Because these have large-scale effects in development, changes in them and in their regulation have profound effects on evolution. I especially enjoyed the section where Carroll combined many bits of information to show us the basic features that must have been present in the first bilaterally symmetric animal, that tiny but promising ancestor of us all. This is one of the bonuses we get for making the extra effort to read the grad-level book.
I find the text very clear and the overall organization - starting with the workings of the major toolkit genes, proceeding through descriptions of how those genes direct the overall shaping of the animal, and on to general considerations of evolution -- proceeds nicely.
[2 June 2007: This was one of the first reviews I wrote and I have added bits as my skills have improved. It got to be a bit patchy, so I have just finished a mafor revision.]
Prelude to a TextReview Date: 2007-06-02
It is a marvellous book, and like a text, it requires and rewards re-reading. Unlike a text, however, it virtually demands to be read in order; not only do the latter chapters build on the earlier ones, but the degree of difficulty in the presentation increases dramatically as the pages turn. As befits a book which assumes a sophisticated readership, there are fewer "detours" into polemics supporting green politics or mocking creationist theory. The photograpsh and the charts are terrific -- full color, clear, and as easy to read and interpret as the difficult subject matter will allow.
Because of the nature of the book, the discussion is less "thesis-bound" than Carrroll's other writings. Rather, he begins with a history of animal life, brings in detail about how embryonic development and genetic control of that process produces the diversity upon which natural selection can act, and weaves the two themes together to demonstrate how the process of forming animal bodies interacts with the changing environment to produce the multiplicity of animal forms we see today. And, Carroll goes on to show, the process is endless and at once aleatory and highly constrained.
I recall an episode of the old "Twilight Zone" series where a British World War One fighter pilot flies through a time warp and lands on an American Air Force base, circa 1960. He talks to one of the airman, and says, "We had no idea how advanced you are." The reader of Carroll's book is likely to have the same thoughts about the field of evo-devo. In Thirty years, these people have gone from the discovery of the nature of the DNA molecule to the brink of an ability to create life a test-tube. I had no idea they had advanced so far so fast.

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Our Food Supply Is At Risk - Uncertain Peril Is The WarningReview Date: 2008-06-25
Required Reading for Educators concerned with the Science, Food & HealthReview Date: 2008-06-06
Uncertain Peril: an informative eye-openerReview Date: 2008-06-05
From a Farmers point of viewReview Date: 2008-07-24
greenhorns to the issue?- This is your textbookReview Date: 2008-06-10
We have learned too late of the gross contamination of our food supply, the 70% of processed foods on our super market shelves that have GMO ingredients, the vast plantations of GMO soybean in Brazil, the open air testing of experimental pharma-drugs and GMOs in Hawaii, the ever more hyperbolus corn fields in our own midwest. These tragedies of monoculture are the result of a deliberate process carried out before our time, and before our involvement in the food system.
While a lot of these biotech developments occurred before my generation got involved in sustainable agriculture, the approval for these technologies and the intellecutal property rights precedents occured at the highest levels. There is a wonderful French film that just came out about Monsanto ( The World According to Monsanto) with a clip of George Bush senior touring the Monsanto research facility and saying "Well if you have any trouble with the FDA let me know, we're in the DEREG business."
With current talk about the 'spike' in food prices funding development for yet another round of "Roundup Ready" crops, with unprecedented hunger pangs, and the recent focus of the Gates Foundation on Biotech for Africa-- what better time to learn what we can from the corrupt history of the Agro-bioscience industry. False promises, superweeds, hegemony and monoculture, lets stop the proliferation of GMO agriculture as soon as we can.


Great read for calico cat fansReview Date: 2008-09-13
Great if you like both cats and genetics!Review Date: 2008-07-18
This book is perfect for anyone looking for a beginners approach to genetics and who also likes cats! I'm thrilled to see it back in print.
For anyone who may be interested in breeding cats or just a plain interest in cats period.Review Date: 2008-05-04
A great gift for any cat loverReview Date: 2008-03-09
Best explanation of the calico phenomenon I have ever read.Review Date: 1999-07-26
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